![]() ![]() To fill this gap, we examined the distinct and common neural responses to the delivery of food and monetary rewards during fMRI. ![]() Yet, the actual consumption of food and the receipt of money have never been directly contrasted in the same experiment, questioning what unique neural processes differentiate those reward types. However, while the value of money is abstract and needs to be learned, the value of food is rooted in the innate processing of sensory properties and nutritional utilization. And, the alterations of EC brain networks in MDD patients may provide new insights into the pathophysiological mechanisms of depression.ĭifferent types of rewards such as food and money can similarly drive our behavior owing to shared brain processes encoding their subjective value. The results showed that compared with HCs, there were significantly altered EC in the cerebellum-neocortex and cerebellum-basal ganglia circuits in MDD patients, which implied that the cerebellum may be a potential biomarker of depressive disorders. ![]() Here, from the perspective of data-driven analysis, we used two different atlases to divide the whole brain into different regions and analyzed the alterations of EC and EC networks in the MDD group compared with healthy controls group (HCs). Therefore, we used a large sample size of resting-state functional magnetic resonance imaging (rs-fMRI) data to investigate the altered effective connectivity (EC) among the cerebellum and other cerebral cortex in patients with MDD. And, there is increasing evidence that the cerebellum is also involved in emotion and cognitive processing and makes outstanding contributions to the symptomology and pathology of depression. However, functional connectivity is undirected. Previous studies mainly focused on cerebrum functional connectivity, and the sample size was relatively small. Major depressive disorder (MDD) is a serious and widespread psychiatric disorder. ![]()
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